Molecular genetic analysis of epidemic dangerous imported Vibrio cholerae El Tor strains isolated in siberian and Far eastern regions of russia. <...> Мoscow: BinoM. laboratoriya znaniy; 2009. (in russian) received 17.12.13 MUltiloCUs seQUenCe-tyPinG oF ViBrio CholerAe strAins With VArioUs ePiDeMiC iMPortAnCe L. <...> Balakhonov Irkutsk Antiplague Research institute of Siberia and Far East, Irkutsk, Russia the allele polymorphism of the housekeeping genes (dnae, lap, recA, pgm, gyrВ, cat, chi, gmd) from the Vibrio cholerae strains with different epidemic importance (n = 41) isolated in siberia and at the Far east during the cholera pandemic Vii was tested. <...> All toxigenic strains isolated at the period of epidemic complications irrespective of time and source of isolation were characterized by the identical allele profile and belonged to the same sequence-type. nine sequence types were detected in non-epidemic isolates. the dendrogram clustering was associated with the serogroup and in some cases with the territory and time of isolation. the structure heterogeneity of the nontoxigenic V. cholerae housekeeping genes was in most cases caused by the synonymous nucleotide replacements (Dn/Ds < 1) indicating the prevalence of the negative V. cholerae at the analyzed genome sites. the revealed distinctions in the structure of housekeeping genes of the V. cholerae with different epidemic importance can be regarded as evidence of various evolutional directions in these strain groups. <...> 1, 2 , Литвинец С.Г.1 ИММУНОхИМИчЕСКАЯ АКТИВНОСТЬ б-АНТИГЕНА YERSINIA pSEuDOTuBERCuLOSIS Институт физиологии Коми НЦ УрО РАН, г. Сыктывкар Получена панель гибридом, продуцирующих моноклональные антитела к иммунохимически неидентичным антигенным эпитопам белковой природы, расположенным на наружной мембране <...>