Журнал Сибирского федерального университета
Journal of Siberian Federal University
Биология
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CONTENTS / СОДЕРЖАНИЕ
Erkin Aydin and Vasif Hasirci
Biodegradable Hard Tissue Implants
– 3 –
О.В. Герасимова, З.Ю. Жарников,
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2010 3 (1)
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Editorial board for Biology:
Sergey I. Bartsev
Alexander Y. Bolsunovsky
Tatiana G. Volova
Eugene S. Vysotski
Nikolai A. Gaevsky
Egor S. Zadereev
Valentina A. Kratasyuk
Elena N. Muratova
J. Woodland Hastings
Frank D. Salisbury
Malcolm K. Hughes
Ernst-Detlef Schulze
Akira Osawa
Takayoshi Koike
Marc D’Alarcao
Mikhail G. Karpinsky
Î.Â. Àíèùåíêî, Ì.È. Ãëàäûøåâ,
Å.Ñ. Êðàâ÷óê, Ã.Ñ. Êàëà÷ёâà, È.Â. Грибовская
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Свидетельство о регистрации СМИ
ПИ № ФС77-28-725 от 29.06.2007 г.
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Journal of Siberian Federal University. Biology 1 (2010 3) 3-17
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УДК 615.46
Biodegradable Hard Tissue Implants
Erkin Aydina
a
b
and Vasif Hasircia,b
*
METU, BIOMAT, Department of Biotechnology,
Biotechnology Research Unit,
06531 Ankara, Turkey
METU, BIOMAT, Department of Biological Sciences,
Biotechnology Research Unit,
06531 Ankara, Turkey 1
Received 4.03.2010, received in revised form 11.03.2010, accepted 18.03.2010
Aging population and decreased physical activity due to increased life standards are two prevalent
and inevitable factors that cause decrease in bone mineral mass, bone quantity, and muscle strength
in the population. These consequences increase the incidence of bone fracture throughout the life
of individuals. Although the bone has a great regenerative capacity compared to most other tissues
or organs in the body, a proper healing of the bone requires appropriate alignment and fi xation of
fractured fragments throughout the process. There are different techniques and tools to provide bone
substitutes with those properties. Most of the available fi xation tools are made from non-eroding
metals due to their inherent stiffness and toughness, the properties necessitated by the load bearing
function of the skeletal system. Ideally, however, an implant should be temporary and be eliminated
from the body as soon as its function is no longer necessary due to potential risks like late stage
infection, bone resorption or immune reactions. For bone implants, due to the need for stabilization of
fi xation devices to the surrounding bone using screws or nails, removal operations may cause severe
morbidity to the newly repaired fracture site. Another equally important problem with use of metal
fi xation devices is their superior mechanical properties that outweigh those of bone, lead the newly
forming bone tissue not to be subjected to mechanical stimulation, which is a necessary requirement
for bone forming machinery. Considering these problems, different biodegradable or bioerodible
materials were suggested to be used in the production of temporary bone fracture fi xation devices.
This paper reviews the developments and trends in the fi eld of biodegradable hard tissue implants,
available materials, and their suitability to the host bone tissue.
Keywords: Hard tissue implants, biodegradable polymers, bioerodible ceramics, biodegradable
metals, biomechanics, biocompatibility.
1. Introduction
Bone is a dynamic tissue in that bone
formation and resorption occurs repeatedly by the
action of osteoblasts and oteoclasts, respectively.
The balance between these two processes is
maintained by the current state of the body and
© Siberian Federal University. All rights reserved
physical activity. This is also valid in healing
and remodeling of a fracture site but with more
parameters, including mechanical stimulus and
condition and location of the fracture site. At
this point, the mechanical properties are critical
because too rigid fi xation causes problems at
* Corresponding author E-mail address: vhasirci@metu.edu.tr
1
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