GRO- α PROMOTES THE PROLIFERATION AND MIGRATION OF TRIPLE- NEGATIVE BREAST CANCER CELLS THROUGH AKT- mTOR SIGNALING PATHWAY (680,00 руб.)

Первый автор	Sun
Авторы	Liang LI., Han B., Cai Z., Wang W., Qu Y.
Страниц	8

ID	945245
Аннотация	Growth- regulated oncogene- α ( GRO- α) has been widely reported in tumorigenesis. However, the specifi c contribution of GRO- α to the malignant behaviors of triple- negative breast cancer ( TNBC) remains unclear. Bioinformatics analyses were conducted using the UALCAN and TIMER databases. The underlying mechanism of action of GRO- α on the progression of TNBC MDA- MB- 231 cells was investigated using CCK- 8, EdU, transwell and Western blotting assays. TNBC tissues exhibited elevated expression of GRO- α, and its high expression was positively correlated with tumor immune cytokines and immune cell recruitment. The growth and migration of TNBC MDA- MB- 231 cells were signifi cantly enhanced following treatment with recombinant GRO- α. Consistently, the protein levels of AKT, p- mTOR, and mTOR in MDA- MB- 231 cells were extremely elevated by recombinant GRO- α. In addition, the malignant behaviors induced by GRO- α were surprisingly attenuated following treatment with mTOR inhibitor Torin1. GRO- α may potentially play a role in the malignant progression of TNBC in an AKTmTOR- dependent manner.

GRO- α PROMOTES THE PROLIFERATION AND MIGRATION OF TRIPLE- NEGATIVE BREAST CANCER CELLS THROUGH AKT- mTOR SIGNALING PATHWAY / S. Sun [и др.] // Бюллетень экспериментальной биологии и медицины .— 2025 .— №11 .— С. 626-633 .— URL: https://rucont.ru/efd/945245 (дата обращения: 18.04.2026)