Белорусский государственный медицинский университет, Минск, Беларусь Optimization of restorative treatment of patients with Helicobacter pylori associated duodenal ulcer Оптимизация восстановительного лечения пациентов с дуоденальной язвой, ассоциированной с Helicobacter pylori ______________________ Abstract __________________________________________________________________________ The rehabilitative possibilities of the combined use of mineral water, probiotics and antisecretory drugs in the treatment of 150 patients with duodenal ulcer associated with Helicobacter pylori, which were divided into three groups similar in clinical characteristics, were studied. <...> It was proved that the use of the standard eradication therapy causes disturbance of intestinal microbiocenosis aggravates the existing dysbiosis, increases the frequency of dyspeptic complaints associated with taking antibiotics. <...> Combined use of probiotics, alkaline hydrocarbonate-chloride sodium mineral water and antisecretory drugs in the treatment of patients with duodenal ulcer is a safety and cost-eff ective technology. <...> This method of restorative treatment of patients with duodenal ulcer associated with Helicobacter pylori can be recommended at all stages of treatment and prevention of disease: in a hospital, polyclinic and sanatorium. <...> Keywords: duodenal ulcer, Helicobacter pylori, eradication therapy, antisecretory drugs, mineral water, probiotics. ______________________ Резюме __________________________________________________________________________ Изучены реабилитационные возможности сочетанного применения питьевых минеральных вод, пробиотиков и антисекреторных препаратов при восстановительном лечении 150 пациентов с дуоденальной язвой, ассоциированной c Helicobacter pylori, которые были разделены на три сходные по клинической характеристике группы. <...> Ключевые слова: дуоденальная язва, Helicobacter pylori, эрадикационная терапия, антисекреторные препараты, питьевая минеральная вода, пробиотики. _________________________________________________________________________________________________ «Кардиология в Беларуси» 2017, том 9, № 3 571 Оптимизация восстановительного лечения пациентов с дуоденальной язвой, ассоциированной с Helicobacter pylori INTRODUCTION Helicobacter pylori is the causative agent of one of the most common infections in the world, occupying a leading position in the development of gastritis, peptic ulcers, B-cell lymphoma and gastric cancer. <...> Eradication therapy is considered successful when reaching at least 80% of the cure [1]. <...> A wide range of acid-suppressive and antibacterial drugs and their constant renewal, unfortunately did not lead to a decrease in the number of patients with acid-related and Helicobacter pylori-associated diseases. <...> Resistance to antibiotics is the main cause of unsuccessful <...>