Batyushin2 DioXiDine inDUCe AntiBiotiC-resistAnt BACteriA 1Southern Federal University, the Academy of Biology and Rostov State Medical University Biotechnology n.a. <...> Ivanovsky, 2 3 Rostov Research Institute of Biotechnology the ability of dioxidine to cause the formation of antibiotic resistance in bacteria was investigated. the study was conducted through the bioluminescence test using recombinant strains of escherichia coli Mg 1655 (psoxs-lux), Mg1655 (pKatg-lux), Mg1655 (precA-lux), Mg1655 (pColD-lux), whose genome contains a plasmid with operon luxCDABe from photobacteria Photorhabdus luminescens under the control of the appropriate stress-inducible promoters of e. coli. <...> Classical methods of resistance mutation frequency determination were also allowed in non-pathogenic and conditionally-pathogenic strains of escherichia coli, Bacillus amyloliquefaciens and Klebsiella pneumoniae. it is shown that dioxidine can cause induction of the promoters , PrecA and Pcda in escherichia coli Mg 1655, which indicates the induction of sos-response in the bacterial cell. induction of Pcda promoter was higher than of PrecA. the maximum induction was observed under the action of 2,25 • 10-5 drug also causes increased induction of psoxs and pkatg promoters, reacting to the presence of superoxide anion radical and hydrogen peroxide. that allows suggesting the possible involvement of oxidative mechanisms in DnA-damaging action of dioxidine. <...> 1 ПРОТИВООПУХОЛЕВЫЙ ЭФФЕКТ АПОПТИН-ПРОДУЦИРУЮЩЕГО РЕКОМбИНАНТНОГО ШТАММА ВИРУСА ОСПОВАКЦИНЫ IN VIVO СВЯзАН С бЛОКИРОВАНИЕМ МИТОТИЧЕСКОГО ДЕЛЕНИЯ ОПУХОЛЕВЫХ КЛЕТОК 1 Институт химической биологии и фундаментальной медицины Сибирского отделения Российской Академии наук, 630090, Новосибирск, Россия; 2Государственный научный Центр биотехнологии и вирусологии «Вектор», 630559, Кольцово, Россия штамма VVdgF-Apos24/2, мышам контрольной группы вводили 0.9% раствор naCl. <...> Образцы опухолевых узлов и клетки асцитической жидкости <...>