To study photodynamic therapy (PDT) effectiveness in polymodal programs including distance gamma-therapy and /or neoadjuvant chemotherapy in patients with malignant tumours of various locations so as to achieve organ-sparing outcomes. <...> Light density ranged from 20 to 100 J/cm2 . 18 patients had distance gamma-therapy at the zone of regional lymph out ow. <...> Response to radiotherapy by WHO classi cation was the following: 12 out of 19 patients – stage I; 6 patients – stage II. <...> Direct outcomes of the treatment have been evaluated by WHO classi cation. <...> Complete tumor resorption was seen in 17 cases, partial resorption – in 8; one patient had disease progression (metastasis in a lymphatic node). <...> Conclusion: PDT in combination with distance radiotherapy and polychemiotherapy in polymodal programs for treating patients with primary and recurrent tumours having accompanying somatic diseases has proven to be effective and can be recommended as an organ-sparing treatment in those who refuse surgical treatment or in patients who are un t for radical radiotherapy and surgical interventions. <...> The cost-effectiveness of Foscan mediated photodynamic therapy (Foscan-PDT) compared with extensive palliative surgery and palliative chemotherapy for patients with advanced head and neck cancer in the UK // Oral Oncology. 2004. <...> D’Cruz A.K., Robinson M.H., Biel M.A. mTHPC-mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients // J. Head & Neck. 2004. <...> Foscan-based photodynamic treatment in vivo: correlation between ef cacy and Foscan accumulation in tumor, plasma and leukocytes // Oncol. <...> Vokes E. Induction chemotherapy for head and neck cancer: recent data // The Oncologist. 2010. 15. <...> The present work analyzes ndings of morphological investigations on the effectiveness of PDT sessions made in experimental acute bacterial peritonitis in rats. <...> Morphological changes have indicated that in the peritoneum of laboratory animals from the studied group ( abdominal cavity sanation with PDT) a sharp decrease in the intensity of in ammatory process takes place. <...> Besides, one can see an increased microcirculation, an activation of mast cell prolipheration and an increased level of eosinophil leucocytes as well as restoration of tissue integrity in opposite to the controls ( abdominal cavity sanation with 2% chlorhexidine). <...> Цель: изучение <...>