SEL’SKOKHOZYAISTVENNAYA BIOLOGIYA [AGRICULTURAL BIOLOGY], 2015, V. 50, ¹ 2, pp. 152-161 ISSN 2313-4836 (Online) doi: 10.15389/agrobiology.2015.2.152rus doi: 10.15389/agrobiology.2015.2.152eng ENDOGENOUS INTOXICATION AND INFLAMMATION: REACTION SEQUENCE AND INFORMATIVITY OF THE MARKERS (review) V.I. SIDEL’NIKOVA, A.E. CHERNITSKIY, M.I. RETSKY Russian Academy of Agricultural Sciences, 114-b, ul. <...> Lomonosova, Voronezh, 394087 Russia, e-mail cherae@mail.ru, retsky@mail.ru A b str a c t According to modern phylogenetic theory of general pathology (V.N. Titov, 2003, 2013) inflammation is a nonspecific biological reaction, providing the removal of excessive amount of highmolecular macromolecules and maintenance of metabolic homeostasis (endoecology). <...> The increase of any metabolite concentration above the physiological range is a violation of the «purity» of intercellular medium. <...> This triggers two nonspecific biological reactions, namely the excretion used to remove «biological waste» of a molecular weight less than 70 kD and the inflammation in case the larger molecules and their complexes should be removed via neutrophils, resident macrophages and endothelial cells. <...> Blood concentration of leukocytes has been used for evaluation of inflammation and intoxication activity for many decades. <...> However, at the molecular level there is a requirement in precise differentiation of metabolites, activating leukocytes, and metabolites, excessively forming as a result of activation, because the last disturb molecular homeostasis and may damage cells and tissues. <...> Validity of leucocytal intoxication index (LII) of Ya. <...> Kalf-Kalif, concentration ratio of low and medium molecular weight substances, average molecular peptides, total and effective albumin as markers of endogenous intoxication (M.Ya. <...> It is shown that primary agent, activating neutrophils and some factors of humoral immunity, is a lipopolysaccharide (endotoxin) of gram-negative microflora (M.Yu. <...> An excess of endotoxin inflow is possible under intestine and liver pathologies, and due to sympathoadrenal system activation, and also with feed and air. <...> The overload of systems and organs of elimination of endotoxin causes secondary immunodeficiency, which becomes the cause of acute and chronic inflammatory processes of various localizations. <...> It is offered to consider lipopolysaccharide of gramnegative microflora as a primary agent of endogenous intoxication and all the metabolites, produces at increased concentrations as a result of polymorphonuclear leukocytes activation such as reactive oxygen species, oxidated proteins, products of lipid <...>