Оригинальные исследования УДК 616.24-007.271-036.12-085.355 :611-018 вЛИяНИЕ ИНгИбИТОРОв ФОСФОдИэСТЕРАЗЫ-4 НА ФУНКЦИОНАЛьНОЕ СОСТОяНИЕ СОСУдИСТОгО эНдОТЕЛИя У бОЛьНЫх хРОНИЧЕСКОЙ ОбСТРУКТИвНОЙ бОЛЕЗНью ЛЕгКИх Е.Г. Кулик, С.В. Нарышкина, В.И. Павленко Амурская государственная медицинская академия (675000, г. Благовещенск, ул. <...> THE INFLUENCE OF PHOSPHODIESTERASE-4 INHIBITOR ON THE FUNCTIONAL CONDITION OF VASCULAR ENDOTHELIUM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE E.G. <...> Endothelial dysfunction is one of the main cardiovascular effects of chronic obstructive pulmonary disease (COPD). <...> Research objective is the assessment of the influence of phosphodiesterase-4 inhibitor on the function of vascular endothelium in patients with COPD. <...> 39 patients aged 43–72, having suffered from COPD, group D, were examined. <...> 20 patients took medicines of the 2nd scheme of pharmacological therapy of COPD (GOLD, 2013), 19 patients in addition to the given scheme took roflumilast (500 mkg/ day, during a month). <...> There were determined concentrations of endothelin-1 (ET-1), L-homocysteine (Hc) and interleukin-6 in the blood serum. <...> In COPD patients the function of vascular endothelium significantly suffered because of hyper-producing of vasoconstrictive substances (ET-1) and disturbing factors (Hc). <...> The level of interleukin-6 was above the norm, and also it was determined direct correlation between serum concentration Нс and interleukin-6. <...> Correlation between inflammation markers (interleukin-6) and endothelial dysfunction (Hc) proofs the entity of system inflammation mechanisms and vascular endothelium damage in COPD. <...> The research results show the positive influence of roflumilast on blood serum concentration Hc and ET-1 in patients with COPD, group D, and widen the pathogenic views about phosphodiesterase-4 inhibitors influence on systematic symptoms <...>