Since 1999
The Journal of scientific articles “Health & education millennium”
Журнал научных статей «Здоровье и образование в XXI веке» №1 2010 том 12
PERSONALIZED CHRONOME (TIME STRUCTURE) COMPLEMENTS GENOME
DETECTING VASCULAR VARIABILITY DISORDERS (VVDS), INCLUDING MESORHYPERTENSION
Cornélissen G. *, Frolov V. **, Chibisov S. **, Kharlitskaya E. **, Halberg F. *
* Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA
** People's Friendship University of Russia, Moscow, Russia
Computer-aided, automatic, inferential statistical, self-help-based preventive health care is
better and cheaper when the personal surveillance is done by a secure Internet, without the need for
a care provider. <...> Key words: time structure, chronome, monitoring, blood pressure, vascular variability
disorders (VVDs)
Introduction
As compared to a genome-based personalized care in the future, self-care based on
monitoring key marker variables, with data analyzed by computer and interpreted for their time
structure (chronome) as-one-goes could involve most people treated for high blood pressure (BP). <...> Outcome studies
assessed the relative risk of morbid events associated with deviations from these norms, thus
identifying Vascular Variability Disorders (VVDs). <...> When the
chronobiologic interpretation of a 24-hour/7-day screening record of data collected automatically at
30-min intervals shows abnormality, and the presence of one or several VVDs is validated in a
repeated monitoring session, treatment is instituted, and its kind and timing are guided by the kind
of VVDs diagnosed (chronotheranostics). <...> Since 1999
The Journal of scientific articles “Health & education millennium”
Журнал научных статей «Здоровье и образование в XXI веке» №1 2010 том 12
As a dividend from the follow-ups on the data flow aimed at the prevention of lifethreatening diseases, of benefit to the individual being screened, medical science may gain
improved reference standards from those who die uneventfully at an advanced age while from those
experiencing an adverse event, new harbingers and/or mechanisms of disease may be detected. <...> The conceptual formulation of home- and Internet-based self-help in medicine has been
eloquently and thoroughly visualized as cybercare for 2028 or 2033 by former U.S. Surgeon
General C. Everett Koop et al. (2). <...> Blood pressure <...>