SPASTIC HYPERTONIA FOLLOWING MCAO IN RATS: ASSESSMENT OF BEHAVIORAL, ELECTROPHYSIOLOGICAL, AND MORPHOLOGICAL PARAMETERS IN DYNAMICS (680,00 руб.)

Первый автор	Sun
Авторы	Qian Q.ZHANG X., Xiu J.
Страниц	9

ID	947213
Аннотация	Gradual changes in muscle resistance after ischemic stroke off er precious insights into the time- course development of spastic hypertonia, but quantitative data about temporal changes in muscle tension are insuffi cient, particularly about changes in muscle properties in post- stroke animal models. In male Sprague- Dawley rats, changes in the motor function, muscle tension, and spastic muscle structure over a 20- day period after permanent middle cerebral artery occlusion ( MCAO) were examined using behavioral tests, electrophysiological test, and muscle fi ber staining. Motor function evaluated by gait analysis and rotarod test performance were impaired from day 0 to day 10. Muscle tension assessed by Modifi ed Modifi ed Ashworth Scale ( MMAS) dropped immediately after MCAO, began to rise on day 3, peaked on day 10, and then deceased somewhat, yet remained relatively high throughout the 20- day observation period. These alterations in muscle tension were also verifi ed by H- refl ex recording. On days 10 and 20 postoperatively, the percentages of type I muscle fi bers in MCAO group were higher than in sham- operated animals. Our results verifi ed a progressive increase in muscle tension and motor dysfunction on days 3–10 after cerebral ischemia, while changes in structural properties of spastic muscles also contributed to hypertonia. The fi ndings may contribute to better understanding of the recovery process in spastic hypertonia quantitatively in animal model after stroke, and are useful for developing new therapeutic approaches.

Sun, T. SPASTIC HYPERTONIA FOLLOWING MCAO IN RATS: ASSESSMENT OF BEHAVIORAL, ELECTROPHYSIOLOGICAL, AND MORPHOLOGICAL PARAMETERS IN DYNAMICS / T. Sun, Q.ZHANG X. Qian, J. Xiu // Бюллетень экспериментальной биологии и медицины .— 2025 .— №12 .— С. 696-704 .— URL: https://rucont.ru/efd/947213 (дата обращения: 23.01.2026)