Имму н о л о г и я УДК 616-092:612.017.1]-008.64-085.275.4 New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin* R.Ameratunga1,2 , S.-T.Woon1 , D.Gillis3 , W.Koopmans1 , R. Steele1,4 1Department Virology and Immunology, Auckland City Hospital, Auckland, New Zealand; 2Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand; 3University of Queensland, Brisbane, Qld, Australia; 4Wellington Hospital, Wellington, New Zealand Common variable immune deficiency (CVID) is the most frequent symptomatic primary immune deficiency in adults. <...> The standard of care is intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (scIG) therapy. <...> In this paper, we review the difficulties with the commonly used European Society of Immune Deficiencies (ESID) and the Pan American Group for Immunodeficiency (PAGID) definition of CVID. <...> We suggest that asymptomatic patients with mild hypogammaglobulinaemia are termed hypogammaglobulinaemia of uncertain significance (HGUS). <...> These patients require long-term follow-up, as some will evolve into CVID. <...> Key words: common variable immunodeficiency (CVID), diagnostics, immunodeficiency-primary Introduction Common variable immune deficiency (CVID) is the most frequent symptomatic primary immune deficiency in adults. <...> The disorder is characterized by recurrent and/or severe infections, autoimmunity, malignancy and allergic disorders. <...> The significance of mutations and polymorphisms in other genes such as TACI, BAFF receptor and MSH5 is less certain. <...> We and others have shown that C104R mutations of the TACI gene do not segregate as expected with symptomatic family Correspondence: R.Ameratunga, Department of Clinical Immunology, Auckland City Address: Hospital, Park Road, Auckland 1010, New Zealand E-mail: rohana@adhb.govt.nz members [13]. <...> It is possible, of course, that some of these ‘healthy’ people with mutations of TACI and BAFF receptor may become symptomatic later in life. <...> The definition published by the European Society of Immunodeficiencies (ESID) and the Pan American Group for Immunodeficiency (PAGID) in 1999 is commonly used [14]. <...> The ESID/PAGID diagnostic criteria comprise three parts: (1) hypogammaglobulinaemia with IgG levels two standard deviations below the mean; (2) impaired <...>