Днепропетровская медицинская академия, Днепр, Украина Enterovirus infection: Hand-Foot-and-Mouth Disease (HFMD) in Ukraine Энтеровирусная инфекция: Hand-Foot-and-Mouth Disease (HFMD) в Украине ______________________ Abstract __________________________________________________________________________ The relevance of the studied problem in Ukraine is determined by the increase in the incidence of patients with enterovirus infection with various clinical forms in recent years. <...> Offi cial statistical registration of this infection in Ukraine is not conducted. <...> But the analysis of infectious diseases among children of Dnipro city and Dnepropetrovsk region over the past 5 years, gives grounds to state an increase in the incidence of enterovirus infection 3.6 times in the form of the following clinical forms: enterovirus meningitis confi rmed by the detection of enterovirus RNA in CSF (68.6%), HFMD (17.9%), herpangina + diarrhea (13.3%). <...> The aim of the work is to study the clinical and epidemiological features of HFMD in children at the present stage, as well as to attract physicians’ attention to the problem of HFMD and, in particular, to the features of heart disease in this disease. <...> The incidence of HFMD in the last 5 years has not been seasonal and has been observed year-round in the form of sporadic cases in the age group of both younger and older age groups. <...> Among the clinical manifestations of HFMD, the most frequent variant of the presentation was the combination of a rather long fever followed by the appearance of polymorphic exanthema (spots, papules and vesicles) on the palmar and interphalangeal surfaces of the hands and soles of the feet in combination with vesicular stomatitis. <...> Repeated episodes of HFMD were registered in 17.64% (n=3) in 6–12 months after the initial episode of HFMD. <...> Heart lesions in two children with this phenomenon were observed in both the fi rst episode and the repeated manifestation of HFMD. <...> A feature of late manifestations of HFMD is desquamation of the nail plates on the hands and feet 2–4 weeks after the infection, as well as repeated cases of HFMD within the next year after the initial episode. <...> A signifi cant proportion of patients with HFMD have a risk of developing myocarditis, which most often has subclinical manifestations, in connection with which all children with enterovirus infection are recommended to conduct an ECG study and determine the serum CF fraction of creatinine phosphokinase. <...> Днепра и Днепропетровской области за последние 5 лет позволяет констатировать рост заболеваемости энтеровирусной инфекцией в <...>