In basic group of hospital patient ALA treatment leaded to reduce glycemia at 8, 11 and 14 o’clock and HbA1с level in 12.0, 9.1, 11.8% and 8.2% accordingly compared to the same ones in control group patients (U, p<0.05). <...> Stressors have a major infl uence upon mood, our sense of well-being, behavior, and health. <...> Acute stress responses in young, healthy individuals may be adaptive and typically do not impose a health burden. <...> However, if the threat is unremitting, particularly in older or unhealthy individuals, the long-term eff ects of stressors can damage health. <...> The relationship between psychosocial stressors and disease is aff ected by the nature, number, and persistence of the stressors as well as by the individual’s biological vulnerability (i.e., genetics, constitutional factors), psychosocial resources, and learned patterns of coping. <...> Psychosocial interventions have proven useful for treating stress-related disorders and may infl uence the course of chronic diseases. <...> It is well known that fi rst depressive episodes often develop following the occurrence of a major negative life event. <...> Furthermore, there is evidence that stressful life events are causal for the onset of depression. <...> Following the perception of an acute stressful event, there is a cascade of changes in the nervous, cardiovascular, endocrine, and immune systems. <...> These changes constitute the stress response and are generally adaptive, at least in the short term. <...> Two features in particular make the stress response adaptive. <...> First, stress hormones are released to make energy stores available for the body’s immediate use. <...> Energy is diverted to the tissues that become more active during stress, primarily the skeletal muscles and the brain. <...> Cells of the immune system are also activated and migrate to “battle stations”. <...> Less critical activities are suspended, such as digestion and the production of growth and gonadal hormones. <...> Finally, in addition to the increased availability and redistribution of energy, the acute stress response includes activation of the immune system. <...> Cells of the innate immune system (e.g., macrophages and natural killer cells), the fi rst line of defense, depart from lymphatic tissue and spleen and enter the bloodstream, temporarily raising the number of immune cells <...>