Материалы IХ Международной научно-практической конференции «Артериальная гипертензия и профилактика сердечно-сосудистых заболеваний» Alyavi A.1 , Alyavi B.,2 Uzokov J.1 1 Republican specialized scientifi c-practical medical center of therapy and medical rehabilitation, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan Tashkent, Uzbekistan 2 Effi cacy of combined antihypertensive treatment with aceinhibitor and i1-imidazoline receptor agonist in patients with metabolic syndrome Background. <...> Hypertension is the key component of the metabolic syndrome. <...> Aim of this study was to assess effi cacy of monotherapy with ACE inhibitor perindopril or I1-imidazoline receptor agonist moxonidine and their combination in patients with metabolic syndrome (MS). <...> The fi rst group 5 mg perindopril, the second group 0.4 mg moxonidine and the third group 5 mg perindopril and 0.4 mg monoxidine were provided. <...> Anthropometric and laboratory analysis are measured at baseline and after 12 weeks. <...> In moderate hypertension BP normalized in 41% and 43% on monotherapy with perindopril or moxonidine, respectively, and in 84% patients given perindopril+moxonidine. <...> No changes of lipid profi le occurred in the fi rst group of patients while signifi cant elevation of high density lipoprotein cholesterol (p<0.05) and tendency to lowering of triglyceride level and LDL-C level were observed in second and third groups but insignifi cantly (p>0.05). <...> Combined treatment with perindopril and moxonidine is more eff ective than monotherapy with each of the above drugs in patients with metabolic syndrome. _________________________________________________________________________________________________ Gorshkov I., Volynkina A., Chernykh T. Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia Alpha-lipoic acid cytoprotective therapy in type 2 diabetes patients with arterial hypertension Aim. <...> To study alpha-lipoic acid (ALA) effi cacy in oxidative stress (OS) modifi cation in type 2 diabetes mellitus (T2DM) patients with diabetes polyneuropathy (DPN). <...> Neuropathic status (NS) indices: Neuropathy Symptoms Score (NSS), Total Symptoms Score (TSS), Neuropathy Disability Score (NDS), Douleur Neuropathique 4 (DN4); oxidative stress parameters: total oxidative capacity (TOC), total antioxidant capacity (TAC), oxidized LDL antibody level (ab-oxLDL); carbohydrate <...>