Cutting Edge: T-Cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for Immune response amplification // J. Immunol. 2004. <...> Platelet depletion in mice increases mortality after thermal injury // Blood. 2006. <...> E. N. Smolina, O. V. Pridantseva, M. B. Kadinskaya, O. V. Galkina, E. O. Bogdanova THE INDICES DYNAMICS OF PLATELET POOL AND THE LEVEL OF TGF-1 IN DIFFERENT FORMS OF ACUTE PANCREATITIS The department of general surgery of State Pavlov Medical University, Saint-Petersburg The results of study of quantitative functional characteristics of platelets are shown in patients with acute pancreatitis. <...> The patients (57 people) with acute pancreatitis were examined: 40 patients had a mild clinical course of acute pancreatitis and 40 patients had a severe clinical course of acute pancreatitis. <...> The circular functional mass of platelets and the level of TGF-1 were determined in dynamics in patients with acute destructive pancreatitis. <...> A correlated analysis was made among the results obtained by means of laboratory and instrumental examinations and clinical course of acute pancreatitis. <...> It was found, that the increase of TGF-1 and circular functional mass of platelets in the course of several days was really a good prognostic factor of clinical course of acute pancreatitis. <...> The data obtained showed that the changes of indices of quantitative and functional characteristics of platelets are the important pathogenetic criterion of prognosis for severity of clinical course of acute pancreatitis. <...> В настоящее время острый панкреатит (ОП) остается одной из наиболее важных проблем неотложной хирургии. <...> Несмотря на расширение возможностей лекарственной терапии, появление малоиивазивиых методов лечения, летальность при этом заболевании сохраняется на достаточно высоком уровне. <...> По литературным данным [1], заболеваемость ОП в Санкт-Петербурге в 2006 г. составила 44.6% от общего числа больных с острыми хирургическими заболеваниями органов брюшной полости. <...> Общая летальность при ОП в последние годы составляет 3-6%, в то же время при тяжёлых формах Oil летальность в различных группах больных колеблется от 20 до 70% [2, 5, 6]. <...> Учитывая <...>