Makarevich A.1 , Aliakseichyk D.1 , Omeljanenko-Gonulal O.1 1 Belarusian State Medical University, Minsk, Belarus 2 National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland Макаревич А.Э.1 , Алексейчик Д.С.1 , Омельяненко-Гонулал О.С.1 , Хоростовска И.2 1 Белорусский государственный медицинский университет, Минск, Беларусь 2 Национальный институт туберкулеза и болезней органов дыхания, Варшава, Польша Old and new biomarkers for assessing severity and adverse outcomes of community-acquired pneumonia (CAP) Роль старых и новых биомаркеров в оценке степени тяжести и неблагоприятных исходов внебольничной пневмонии (ВБП) ______________________ Abstract __________________________________________________________________________ Background. <...> Early prognostic assessment by the clinical scale with the biomarkers panel is crucial for the optimized management of severe CAP. <...> The aim was to evaluate the usefulness of several biomarkers and thyroid hormones in combination with the CURB-65 scale to understand how these biomarkers might be used in clinical practice for CAP severity assessment as well as the relationship between these biomarkers and adverse clinical outcomes. <...> A total 185 in-patients with proven CAP of CURB-65 class 2–5 were enrolled to the study. <...> We measured the values of: C-reactive protein (CRP), procalcitonin (PCT), d-Dimer (d-D), copeptin (CP), adrenomedulin (ADM), total cholesterol (TCL) and thyroid hormones as free triodtronin (FT3 tetrajodtironina (FT4 ), ) and thyroid stimulating hormone (TSH). <...> Intensification of CAP severity and appearence of in-hospital mortality (IHM) were associated with increased values of infection and inflammation biomarkers (CRP, PCT), disorders of coagulation (increase of d-D level) and lipid metabolism (decrease of TCL level) as well as vascular tone (CP, ADM). <...> Non-survivors had significantly the higher values of CRP, PCT, d-D and CP vs. survivors. <...> PCT, d-D showed a significantly higher concentrations in patients requiring vasopressors support (VS) vs. those with stable haemodynamics (by 15%, 14 and 2.4 times respectively). <...> Both CP and ADM values were significantly correlated with duration of ICU stay (r=0.43; 0.91) as well as CP with need for VS (r=0.54). <...> The levels of FT3 the control group as well as in patients requiring invasive mechanical ventilation (IMV). <...> There were <...>