UDC 541.64:532.73 PREPARATION OF NANOPARTICLES OF LOW-MOLECULAR CHITOSAN COMPLEXES WITH ISONICOTINIC ACID HYDRAZIDE V. A. Kuznetsov1 1 , M. V. Bakalova1 A. I. Slivkin1 , G. V. Shatalov1 , A. M. Semenov1 , Wael Shehta M.2 Chair of Polymer Science and colloids, Voronezh State University 2 faculty of science Zagzig University (Egypt) Поступила в редакцию 02.04.2015 г. <...> Получены наночастицы комплексов низкомолекулярного хитозана с гидразидом изоникотиновой кислоты (изониазида), сшитого триполифосфатом натрия (TPP). методом ИКспектроскопии подтверждено состав и структура образованных комплексов. <...> Isonicotinic acid hydrazide (isoniazid) loaded nanoparticles of chitosan (CS) cross-linked with tripolyphosphate (TPP) were prepared. <...> The prepared nanoparticles were characterized by FT-IR spectroscopy to confirm the cross-linking reaction between CS and cross-linking agent. <...> Up to about 50% of isoniazid were loaded into the nanoparticles and the average size of nanoparticles ranged from 120 to 200 nm. <...> Chitosan, nanoparticles, isonicotinic acid hydrazide , Over the past decades has been actively working to create systems drug delivery, allowing to increase the circulation time of the drug in the blood, protect it from the enzyme systems of the body, including molecules that provide the target delivery, potentially leading to the creation of a new generation of drugs. <...> A © kuznetsov V. A., bakalova M. V., Shatalov G. V., Wael Shehta M., Slivkin A. I., Semenov A. M., 2015 significant advantage of chitosan compared to other is reactive polysaccharides (hydroxo- and amino groups that are allows to obtain derivatives with the required characteristics. <...> In a polymer matrix on the basis of chitosan and its derivatives can be incorporated substances of different nature - proteins, peptides, nucleic acids, vitamins, antineoplastic agents, etc. [3,4]. <...> Further more, depending upon the molecular weight and the degree of modification of the polymer by various substituents can be prepared nanoparticles with different size and charge [5]. <...> Use chitosan particle formations on the ВЕСТНИК ВГУ, СЕРИЯ: ХИМИЯ. <...> ФАРМАЦИЯ, 2015, № 2 17 Kuznetsov V. A., Bakalova M. V., Shatalov G. V., Wael Shehta M., Slivkin A. I., Semenov A. M. basis there of is for intravenous administration step <...>