Purpose: To specify margins and multiple character of tumoural lesions in patients with skin cancer using uorescent diagnostic techniques. <...> This research work has been made at Hertzen’s Institute of Oncology of Healthcare Ministry of Russia. 237 patients have been studied. <...> The majority of patients were females (61.6%). <...> Indications for the discussed technique application were: to specify margins of skin cancer of various location before special therapy, to look for latent cancer foci. <...> Depending on the purpose all studied patients were divided into two groups: patients with topically-spread cancer of head and neck skin who had FD before surgical treatment , and patients with skin cancer of various locations who had FD before PDT. <...> FD has allowed to specify margins of previously detected tumoural foci in 100% of patients. <...> It has allowed to better de ne the resection volume in the rst group of patients and to plan the area for laser irradiation in the second group. <...> Besides, 506 foci of additional uorescence were observed in 118 (53.1%) out of 222 patients from the second group. <...> In 63 (28.4%) of them skin cancer was diagnosed after morphological examination. <...> Kennedy J.C., Pottier R.H., Pross D.C. Photodynamic therapy with endogenous protoporphyrin IX: Basic principles and present clinical experience // J. Photophem. <...> Liutkevicite-Navickiene J., Mordas A., Simkute S., BloznelytePlesniene L. Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester // Article in Lithuanian, Medicina (Kaunas). 2009. 45 (12). <...> Цель работы: уточнение границ и выявление множественного характера опухолевого поражения у больных раком кожи флюоресцентными методами исследования. <...> Работа выполнена на базе ФГБУ «МНИОИ им. <...>