Biology 1 (2016 9) 21-32 ~ ~ ~ УДК 615.462 Biodegradation of PHA in vivo Ekaterina I. Shishatskaya* Institute of Biophysics of SB RAS 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia Received 21.11.2015, received in revised form 24.01.2016, accepted 07.03.2016 The present review summarizes the literature data on the degradation dynamics of polyhydroxyalkanoates (PHAs) in vivo and the authors’ results obtained over a more than ten years of research, which included implantation of experimental polymer items shaped as microparticles, fi lms, fi laments, and 3D constructs subcutaneously, intramuscularly, and into internal organs of animals for long periods of time. <...> The study shows that PHA degradation is determined by the chemical structure of the polymer, the shape of the implant, and implantation site; PHA degradation is slow, occurring via humoral and cellular pathways, usually beginning on the surface of the implants, with no local defects developing or strength decreasing dramatically. <...> PHA biodegradation involves macrophages and foreign body giant cells. <...> PHA products are resistant to the effects of biological media and are capable of functioning in vivo for between several months and one year or longer. <...> Биодеградация ПГА in vivo Е.И. Шишацкая Институт биофизики СО РАН Россия, 660036, Красноярск, Академгородок, 50/50 В представленном обзоре обобщены литературные данные по динамике разрушения полигидроксиалканоатов (ПГА) in vivo и собственные результаты авторов, полученные за период исследований более десяти лет в экспериментах с имплантацией животным полимерных изделий в виде микрочастиц, пленок, нитей и 3D-форм на длительные сроки, достаточные для определения периодов полуразрушения имплантатов. <...> В биодеградации ПГА наиболее значима роль макрофагальных иммунокомпетентных клеток фагоцитирующего © Siberian Federal University. <...> All rights reserved * Corresponding author E-mail <...>