Generala Rodina, Orel, 302019 Russia, e-mail juliemons@yandex.ru A b s t r a c t Resource-saving technologies contribute to the reproduction of the soil fertility and increase sustainability of agrocenoses. <...> Legumes are most relevant to the modern requirements for formation of ecological balance. <...> They form a multicomponent symbiosis with various groups of useful soil microflora, which not only improves soil properties and increase the yield and its quality, but also makes them a valuable precursor in the rotation. <...> In this regard, promising search and practical use of new microorganisms with multifunctional properties that will improve the economic efficiency of legume cropcultivation. <...> Of particular interest is the use of ACC-utilizing bacteria having a versatile anti-stress effect on plants. <...> We have carried out a study on the impact of the introduction of promising strains ACC utilizing rhizobacteria ( 3P-4) and nodule bacteria ( Ep4 and 634b) on efficiency of cultivation of the northern soybean ecotype Svapa in Orel Region depending on mineral nutrition (NPK 100 % and NPK 70 %). <...> The strain of nodule bacteria was used for inoculation of seeds in the amount of 200 g per hectare seed rate. <...> Strains of associative ACC utilizing microorganisms were added to the rows in the seedling stage (10 % solution). <...> NPK was applied to the soil before planting in the form of fertilizer mixture with the percentage of mineral nutrients 10:26:26. <...> Biochemical assessment of the quality of soybean was performed in the laboratory conditions. <...> In forming symbioses with introduced microflora the soybean agrocenoses were more environmentally adaptable, which was reflected in increasing the productivity in drought years by 35-98 %. <...> The positive effect of the bacteria was evident in increasing the grain protein content by 34 %. <...> Getting a high yield and high yield quality of the studied soybean variety due to formation of effective plant-microbe system leaded to the increase of total protein up to 1.05-1.30 t/ha. <...> It was found that the use of rhizobacteria together with nodule bacteria ensured maximum economic benefit and allowed to obtain cheaper and high-quality protein with high profitability. <...> This will reduce the costs associated with the application of mineral fertilizers without crop losses. <...> The reduction of the productivity of agrocenoses, of crops quality and natural soil fertility as the result of agricultural production <...>