Обзоры УДК 611.018.26:546.221.1:616.12 Vascular dysfunction and periadVentitial adipose tissue D. Tsvetkov, I.A. Szijбrtу, N. Wang, J.-Y. Tano, M. Gollasch Charitй – University Medicine, Experimental and Clinical Research Center, a joint cooperation of the Charitй and Max Delbrьck Center for Molecular Medicine in the Helmholtz Association (Lindenberger 80, Weg 13125 Berlin, Germany) Keywords: body mass index, adipocytes, vasoactive factors, hydrogen sulfide. <...> VASCULAR DYSFUNCTION AND PERIADVENTITIAL ADIPOSE TISSUE Tsvetkov D., Szijбrtу I.A., Wang N., Tano J.-Y., Gollasch M. Charite University Medicine Berlin (80 Lindenberger Weg 13125 Berlin, Germany) Summary. <...> Over the last years, concerted efforts have helped to uncover and understand the basic mechanisms of periadventitial regulation of arterial tone by perivascular adipose tissue. <...> Basically, perivascular adipose tissue serves as source for “Adipocyte-derived relaxing factor” (ADRF), an essential player in the control of vascular tone of visceral and other arteries. <...> Importantly, its disturbed local, paracrine activity is able to cause vascular dysfunction. <...> Hydrogen sulfide (H2S) is a putative candidate for ADRF, which has received increased attention. <...> The importance of this and other candidates for periadventitial vasoregulation has been recently explored in rodent models of obesity, hypertension and metabolic syndrome. <...> Pharmacological tools have been successfully used to clarify the role of potassium channels involved in these conditions. <...> Vasoactive factors of adipocytes or their receptors could represent targets for the development of novel cardiovascular drugs. <...> Obesity in the last few decades has rapidly developed into a major health problem affecting a large portion of the world population. <...> Cardiovascular disease remains the leading cause of death worldwide fueled by arterial hypertension and diabetes mellitus. <...> These two risk factors are driven by the occurrence of obesity, which increases in all countries of the world. <...> In North America, the population of people with overweight (body mass index, BMI>25 kg/m2) or obesity (BMI>30 kg/m2) exceeds the population with normal weight and underweight, with the latter now constituting a minority in the population. <...> Results of the Gollasch Maik – MD, PhD, Section Nephrology/Intensive Care of Experimental and Clinical Research Center; e-mail <...>