The X-ray analysis indicates that the V atom in the complex is in the octahedral coordination. <...> Transition metal complexes with various ligands have received much attention because they exhibit interesting biological activities. <...> The increasing interest in the coordination chemistry of vanadium arises from its well-established chemical and biological functions [ 1—5]. <...> Due to the structural similarity between vanadates and phosphates and the ability to be transported into cells through the anion channel of plasma membranes [ 8, 9 ], many vanadium compounds have been shown to increase glucose transport into cells and oxidation via glycolysis [ 10, 11 ]. <...> Oxovanadium(IV) sulphate has been demonstrated to possess the oral insulin-like activity similar to that of vanadates but with lowered toxicity [ 12 ]. <...> Oxovanadium(IV) salts, however, are known to be poorly absorbed and are less bio-available compared to vanadates [ 13, 14 ]. <...> Therefore, a number of low molecular weight vanadium complexes have been prepared and studied on their insulin-like activity in an attempt to improve the vanadium bioavailability [15—17 ]. <...> Considering hydrazone ligands to be bioactive species [ 19 ], in the present paper, we report the synthesis, characterization, and insulin-like activity of a new vanadium complex [VOL(OMe)(MeOH)], where L is the dianionic form of the hydrazone ligand N-(3,5-dichloro-2hydroxybenzylidene)-2-methylbenzohydrazide (H2L). <...> VO(acac)2, 3,5-dichlorosalicylaldehyde, and 2-methylbenzohydrazide were purchased (Lancaster) and used as received. <...> All other reagents were of © Han S., Wang Y., 2015 Vanadium complexes have been proved to possess an interesting insulin-like activity. <...> The reaction of VO(acac)2 with N-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H2L) in methanol affords a new mononuclear vanadium (V) complex [VOL(OMe)(MeOH)]. <...> The structure of the complex is characterized by physicochemical methods and single crystal X-ray diffraction. <...> Elemental analyses of C, H, and N were carried out on a 2400 Series-II CHN analyzer. <...> The in vitro insulinmimic activity was determined according to the literature method [ 17 ]. <...> Synthesis of the complex. 3,5-Dichloro-2-hydroxybenzaldehyde (0.19 g, 1.0 mmol) and 2-methylbenzohydrazide (0.15 g, 1.0 mmol) were dissolved and mixed in methanol (20 ml). <...> The mixture was stirred at room temperature for 10 min to give <...>