118 Section MOLECULAR ANTHROPOLOGY – NEW ADVANCES and the Central Tuvinians, are characterized by the maximum range of haplogroups. <...> More than a quarter of the Y-gene pool belonged to North Eurasian haplogroups Q-M242, the fi fth part of the gene pool consists of West Eurasian haplogroup R1a1a-M198. <...> The genetic structure of the studied populations of Tuvinians and Todzhintsy was computed by the analysis of molecular variance (AMOVA), with Fst=0.085. <...> The cluster analysis of the populations of Southern Siberia on the matrix of genetic distances (average d=0.4) has shown that all Tuvinians and Todzhintsy formed a united cluster together with Khakas-Sagaytsy. <...> Our results indicate the general background in the origin of the populations of Tuvinians and the preservation of an ancient “Siberian” layer (N1b-P-43, N1c1a-M178, Q-M242) in the gene pool of Todzhintsy in the conditions of geographical isolation in mountain and taiga areas. <...> It can be emphasized that the conditions formed a refugium, where the gene pool kept traces of the ancient population of Southern Siberia. <...> INFLUENCE OF GENETIC POLYMORPHISM +1663A/G TNFR2 ON THE DEVELOPMENT OF CHRONIC TRUE ECZEMA Denisova Ya., Chournosov M., Krikun E. Belgorod National Research University, Belgorod, Russia Among the cases of chronic dermatosis, eczema makes 30 to 40%. <...> The rise of sickness rate, the chronicity of the disease process, the frequent recurrence of its course, insuffi cient effect of the treatment methods make chronic eczema the most pressing problem in the modern dermatology. <...> At present the leading pathogenic link of eczema development is considered to be a marked immunological disorders. <...> The main role here is played by T-lymphocytes that bear specifi c receptors to the antigen and discharge a number of proinfl ammatory cytokines as well as the factors of tumor necrosis and their receptors. <...> In connection with this, the object of this research work is the study of the role of genetic polymorphism +1663A/G TNFR2 in the development of chronic true eczema. 363 persons were examined (58 patients and 305 persons of the control group), all of Russian nationality, natives of the Central Chernozem region of the RF and having no blood relationship. <...> The extraction of genome DNA from peripheral blood is made with the method of phenol-chlorophorm extraction. <...> PCR was made on the amplifi er IQ 5 (Bio-Rad) in the real time mode of operation with the use of DNA polymerases <...>