Since 1999
Электронный сборник научных трудов «Здоровье и образование в XXI веке» №1 2010 том 12
THE DIAGNOSTIC VALUE OF THE SPHYGMOCHRON IN THE EARLY
DIAGNOSIS OF PRE-HYPERTENSION AND HYPERTENSION.
*Cornelissen G., **Chibisov S.M., **Kharliskaya E.V.,
*Halberg F., **Ertueva M., ***Zaslavskaya R.M. **Agarwal R.K.
*Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA
**People's Friendship University of Russia, Moscow, Russia
*** The Moscow clinical hospital № 60, Russia
Introduction
The likelihood of stroke or cardiac death can be immediately reduced by chronobiologically assessing
blood pressure and heart rate variability and by optimizing the efficacy of timed treatment rather than
relying on an unacceptable and often inaccurate spotcheck and treating by convenience rather than
pertinence. <...> Needed are: detection of nocturnal abnormality when medication may no longer be effective
(or is too effective) neither seen during office visits by day; detection of circadian hyperamplitude-tension
(CHAT) associated with a risk of stroke and kidney disease greater than other risks (including
“hypertension” when all risks are assessed concomitantly); detection of CHAT as high risk among
normotensives who may not need anti-hypertensive medication; individualized inferential statistical
testing to determine whether a drug or non-drug intervention such as autogenic training (relaxation) is
effective and for how long (detecting any initial and later success or failure), some of which conditions
otherwise are not found without chronobiology; individualization of treatment timing, since the same
dose of the same medication can further lower the subject's blood pressure average and circadian
amplitude when the timing of daily administration is optimized, as ascertained by sequential testing and
parameter tests. <...> Method
A 19-year-old female student provided two 7-day profiles of automatic around-the-clock blood
pressure and heart rate measurements at 30-minute intervals, assessed chronobiologically by
sphygmochron (1-3), allowing a comparison of the cosinor with a classification by dipping (4-9). <...> Once abnormality is detected, continuous vascular monitoring is indicated (1).
250
Monitoring Profile over Time;
Computer Comparison with Peer Group Limits
Blood Pressure (BP) and Related Cardiovascular Summary. <...> Original data: systolic blood
student, ME. © Halberg.
pressure (SBP <...>